In a new study, German researchers showed the effect of sleep on infection reduction.
Scholars in Germany discovered why sleep sometimes can be the best medicine, according to Health News. Sleep improves the ability of some immune cells to stick to their desired goals. The study, conducted at the University of Tübingen in Germany, shows how sleep can also fight infections.
“T cells” are a type of white blood cell that is very important in immune response. When T-cells detect a target such as the virus-infected cell, they activate the “Integrin” adhesive proteins to allow them to stick to the target and eliminate them. Although there is a lot of information about integrin activator signals, the signals that are responsible for modifying the ability of T cells to adhere to the target are less well-known.
Stoyan Dimitrov, the head of the study and his colleagues, decided to examine the effects of a different group of signaling molecules known as GPCRs. Many of these molecules can suppress the immune system, but their ability to incite T cells to activate integrin and binding to the cells is unknown.
They found that GPCRs molecules prevented the activation of T-cell integrin after target detection.
Dimitrov added: Levels of molecules needed to inhibit the activity of intriguing in many conditions, such as tumor growth, malaria infection, “chemotherapy” or “hypoxia”, and stress was studied. Perhaps this method is related to the suppression of immunity associated with these diseases.
The research group compared T-cells from healthy volunteers at bedtime and at rest. The level of activity of integrin cells derived from sleep volunteers was much higher than those obtained from awake volunteers. They found that the efficacy of integrin activity in sleep cells is due to the activity of GPCRs molecules.
“Our findings suggest that sleep has the ability to increase the efficiency of T-cell responses,” said Luciana Besedovsky, Luciana Besedovsky, author of the study.
The study was published in the journal Journal of Experimental Medicine.